Consistent with mitragynine’s pharmacology that includes partial µ-opioid receptor agonism with little recruitment of the respiratory depressant activating β-arrestin pathway...

Some people have experienced different effects, including weight loss. However, there are also users who report that kratom may be making them gain weight. But, is this possible? Does kratom cause weight gain? We’ll explore this subject in this article.

Kratom’s two primary alkaloids — 7-hydroxymitragynine and mitragynine — are responsible for producing most of its many pharmacological effects. Alkaloids are organic compounds containing nitrogen, an extremely broad category that includes chemicals like ephedrine, caffeine, an...