Can stress cause swollen lymph nodes? While it's unlikely that stress alone directly leads to swollen lymph nodes, the relationship between stress and your body's immune response is complex. When you're stressed, your body may become more susceptible to infections, which can, in turn, cause lymph nodes to swell. This swelling is often a sign that your immune system is fighting off something. However, the science behind stress and swollen lymph nodes isn't fully understood, and more research is needed to clarify this connection. Always consult a healthcare professional if you notice unusual swelling.