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Pain following surgery is among the moderate to moderately severe pains that can be relieved with tramadol. It is also used to treat pain that is severe enough to need opioid treatment, as well as when other painkillers were ineffective or intolerable. Extended-release tablets or capsules are used to treat persistent, chronic pain.

Tramadol is a member of the class of medications known as opioid analgesics. It reduces pain by acting on the central nervous system (CNS).