Kamagra Gel
Sildenafil
Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension.[8][4] It is unclear if it is effective for treating sexual dysfunction in women.[8] It is taken by mouth or injection into a vein.[8] Onset is typically within 20 minutes and lasts for about 2 hours.[8]
Common side effects include headaches, heartburn, and flushed skin.[8] Caution is advised in those with cardiovascular disease.[8] Rare but serious side effects include a prolonged erection that can lead to damage to the penis, vision problems, and hearing loss.[8] Sildenafil should not be taken by people on nitrates such as nitroglycerin (glycerin trinitrate), as this may result in a serious drop in blood pressure.[8]
Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis.[8] It requires sexual arousal, however, to work.[8] It also results in dilation of the blood vessels in the lungs.[8]
Pfizer originally discovered the medication in 1989 while looking for a treatment for heart-related chest pain.[9] It was approved for medical use in the United States and in the European Union in 1998.[5][8][9][10] In 2017, it was the 217th most commonly prescribed medication in the United States, with more than two million prescriptions.[11][12] In 2017, it became available as a generic medication after final patents by Pfizer expired.[13] In the United Kingdom, it is available over the counter.[14] Most of the Active Pharmaceutical Ingredient (API) in Sildenafil, Sildenafil citrate, is produced in Pfizer's Ringaskiddy complex, County Cork, which is Pfizer's largest production facility outside of the United States.[15] Source: Wikipedia
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