SGT-151, also known as Cumyl-PEGACLONE, is a synthetic cannabinoid that has been sold as a designer drug. This article aims to provide a comprehensive overview of SGT-151, including its structure, legal status, metabolism, and toxicity.
Structure and Properties
The chemical structure of SGT-151 is C25H28N2O, with a molar mass of 372.512 g/mol. This unique gamma-carboline core structure is similar to other gamma-carboline cannabinoids disclosed by Bristol-Myers Squibb in 2001. 5f-sgt-151 dosage
Legal Status
SGT-151 has been classified as a narcotic substance in Sweden since January 18, 2019. In the United States, the DEA temporarily placed SGT-151 into Schedule I status starting on December 12, 2023, for up to two years. If the DEA does not file for permanent placement, the temporary Schedule I order will expire on December 12, 2025.
Metabolism and Toxicity
Studies have investigated the metabolism of SGT-151 in human liver microsomes and urine samples. The metabolites were identified and ranked by their mean peak area ratios over all analyzed urine samples. The metabolites were found to undergo various biotransformations, including:
- N-Dealkylation
- Monohydroxylation
- Dihydroxylation
- Hydrolytic Defluorination
Forensic Analysis
Forensic analysis of SGT-151 has been conducted using techniques such as:
- GC/MS
- LC–ESI-QToF-MS
These methods have helped identify the presence of impurities in the substance and its metabolites in urine samples.
Toxicity and Fatalities
There have been reports of fatalities associated with the use of SGT-151. A retrospective study found four cases of death involving the novel synthetic cannabinoid 5F-Cumyl-PEGACLONE, which is a fluorinated variant of SGT-151.
Key Points
- Chemical Structure: C25H28N2O
- Molar Mass: 372.512 g/mol
- Legal Status: Narcotic substance in Sweden, temporarily placed into Schedule I status in the United States
- Metabolism: Undergoes various biotransformations, including N-dealkylation, monohydroxylation, dihydroxylation, and hydrolytic defluorination
- Forensic Analysis: GC/MS and LC–ESI-QToF-MS
- Toxicity and Fatalities: Reports of fatalities associated with the use of SGT-151 and its fluorinated variants
References
- Ana Luzio, Joana Couceiro, Carla Ferreira. Assessing the content of a package of SGT-151 sold online. PMC - NCBI, 28 Sept 2021.
- Human phase I metabolism of the novel synthetic cannabinoid 5F-SGT-151. PMC - NCBI.
- CUMYL-PEGACLONE - Wikipedia.
- A retrospective look at the role of synthetic cannabinoid receptor agonists. SpringerLink.
- 5f-sgt-151 kaufen
Conclusion
SGT-151 is a synthetic cannabinoid with a unique gamma-carboline core structure. It has been classified as a narcotic substance in Sweden and temporarily placed into Schedule I status in the United States. The metabolism of SGT-151 involves various biotransformations, and forensic analysis has been conducted using GC/MS and LC–ESI-QToF-MS. Reports of fatalities associated with the use of SGT-151 and its fluorinated variants highlight the potential dangers of this substance.