What is NAD IV therapy? NAD IV therapy is a type of treatment that involves the intravenous administration of high doses of nicotinamide adenine dinucleotide (NAD), a coenzyme found in every cell of the body. NAD IV therapy is a type of treatment that involves the intravenous administration of high doses of nicotinamide adenine dinucleotide (NAD), a coenzyme found in every cell of the body.