Investing in Yu-Gi-Oh! booster boxes require a deep understanding of the market, nostalgia, and the impact of specific sets on the game. Boxes like "Legend of Blue-Eyes White Dragon," "Invasion of Chaos," and "Magician's Force" are prime examples of sets that have appreciated significantly over time. These boxes, especially in the first edition, are not just pieces of the game’s history but also valuable assets that can yield significant returns for savvy investors.