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Numerous studies have been carried out to synthesize thyroid hormone analogs that mimic the actions of the natural hormones. The objective of most of these efforts has been to develop thyromimetics that lower plasma cholesterol without adverse cardiac effects. A series of thyroxine analogs and methods of synthesis are described in U.S. Pat. No. 3,109,023. Thyroid hormone agonists that are highly selective for the thyroid hormone receptor (TR) β-subtype are described in U.S. Pat. No. 5,883,294 and WO 00/39077. U.S. Pat. No. 5,284,971 describes a class of thyromimetics, which have the distinguishing characteristic of a sulfonyl bridge in the diphenyl core. U.S. Pat. No. 6,534,676 describes a thyroid hormone analog 3,5-diiodothyropropionic acid (“DITPA”) for treating patients with congestive heart failure.
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In 1941 Drew created the model for a national blood collection program for the Red Cross. You can imagine how he felt when the Red Cross announced that African Americans could not donate blood. After a public outcry against this policy, the Red Cross accepted black donors but segregated the contributed blood, at the insistence of the United States Army. Drew protested against this new policy. “There is no scientific basis for the separation of the bloods of different races except on the basis of the individual blood types or groups,” he declared.
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