As the most abundant antioxidant in your body, GSH is responsible for maintaining oxidative balance in each of your cells. Vitaminhaat's Liver Maximizer (NAC) Liver Supplement Supports Liver Health Liver-Health Vitamins, Nutrients and Herbs Supports Liver Detoxification, Protection and Regeneration Activates Alcohol Metabolizing Enzymes Provides Liver Protection Factors.
Taking glutathione as a nootropic supplement does not adequately restore GSH levels in your brain because it can’t cross the blood-brain barrier. This vastly underrated nootropic, NAC easily penetrates the blood-brain barrier and raises glutathione levels in your brain. Vitaminhaat’s Liver Detox contains Milk Thistle, a traditionally used western herb to support liver function and liver health.
NAC has been used to treat acetaminophen poisoning for decades. In USA every year there are 56,000 ER visits from paracetamol overdose, resulting in at least 100 deaths. NAC provides the glutathione our liver needs to fight off the metabolite NAPQI in paracetamol that does severe liver damage.
As a Liver Antioxidant, NAC helps prevent glutamate toxicity, boosts dopamine, and reduces inflammation, oxidative and free radical damage.
Acetylcysteine, also known as N-acetylcysteine (NAC), is a modified amino acid that is used as an antidote for acetaminophen overdose to prevent hepatic injury. Acetylcysteine is a hepatoprotective agent and has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury.
Background
Acetylcysteine is a modified amino acid that is used to reverse the toxic effects of acetaminophen overdose and prevent acute liver failure. The amino acid cysteine has a thiol side chain that can undergo redox reactions and thus has antioxidant activity. Importantly, cysteine is required for synthesis of glutathione (a tripeptide of cysteine, glycine and glutamic acid) that is an essential intracellular antioxidant, providing protection against free radicals and other intracellular toxins including intermediates of drug metabolism.
Glutathione can become depleted in patients with malnutrition, chronic debilitating illnesses and chronic alcoholism, and becomes acutely depleted in patients with acetaminophen overdose leading to formation of toxic adducts of acetaminophen metabolites with essential intracellular molecules. Restoration of glutathione stores ameliorates the cell injury from acetaminophen.
In multiple clinical trials, administration of acetylcysteine (also referred to as N-acetylcysteine or NAC) within 10 hours of an acetaminophen overdose effectively prevented serious liver injury. Subsequent studies suggested that administration even after 10 hours was partially effective and may also be beneficial in other, non-acetaminophen causes of acute liver failure, including drug induced liver injury.