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Revlimid (Lenalidomide) For The Therapy Of Mantle Cell Lymphoma (MCL)

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For which situations is this drug accepted? A blood thinner will assist forestall blood clots for patients who're being treated with a mix of an immunomodulatory agent, akin to thalidomide (Thalomid), lenalidomide (Revlimid), or pomalidomide (Pomalyst), and dexamethasone, which is a steroid.
Lenalidomide is used to treat multiple myeloma (bone marrow cancer ), either together with another medication or after stem cell transplant. Focused therapy is usually used to deal with a number of myeloma. It usually includes a mixture of drugs and excessive-dose chemotherapy.
In sufferers who responded to lenalidomide, they discovered that the bone marrow aspirates earlier than remedy confirmed decreased expression of the set of the genes needed for erythroid differentiation. Response to REP was higher in 25%, similar in forty four%, and inferior in 31% of sufferers, compared with the previous lenalidomide-containing regimen.
The imply yield was 6 × 106 CD34+ cells, with just one of 5 sufferers reaching the mobilization goal. 13 Rosen LS, Gordon D, Kaminski M, et al. Zoledronic acid versus pamidronate in the remedy of skeletal metastases in sufferers with breast most cancers or osteolytic lesions of multiple myeloma: a part III, double-blind, comparative trial.
An increase in new (second) cancers has occurred in sufferers who obtained REVLIMID and melphalan, or a blood stem cell transplant, including sure blood cancers, similar to acute myelogenous leukemia (AML), and myelodysplastic syndrome (MDS) and certain different types of cancers of the pores and skin and different organs.
However Revlimid nonetheless not the primary choice in these sufferers: in its closing draft steerage, revealed as we speak, GOOD recommends Revlimid together with dexamethasone as an choice for previously untreated myeloma in adults who aren't eligible for a stem cell transplant only if sufferers can't tolerate the older drug, thalidomide, which may trigger bruising, breathlessness and increased threat of an infection.