BPC 157 & Healing Your Body
What is BPC 157?
BPC 157 is a sequence of amino acids with a molecular formula of 62 carbons, 98 hydrogens, 16 nitrogens, and 22 oxygen atoms (C62-H98-N16-O22).
Should you care to know the nitty-gritty specifics, that comes out to a fifteen amino acid sequence of the following:
L-Valine, glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolylglycyl-L-lysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanylglycyl-L-leucyl-; glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolylglycyllysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanylglycyl-L-leucyl-L-valine.
That's the long, fancy name for BPC 157.
BPC, for reasons you're about to discover, stands for “Body Protecting Compound”. Your body already makes it in your own gastric juices in very small amounts, where it serves to protect and heal your gut. But if you can get the super concentrated version and get it into your system, it has an extremely high level of biological healing activity just about anywhere you put it.
BPC-157 is a 15-amino acid long peptide, and a part of a naturally occurring peptide in the human stomach (BPC-157 is derived from human gastric juices). It is a signalling peptide; it signals for certain processes to take place in the body.
What Does BPC 157 treat?
BPC 157 is surprisingly free of side effects, and has been shown in research that's been happening since 1991 to repair tendon, muscle, intestines, teeth, bone and more, both in in-vitro laboratory “test-tube” studies, in in-vivo human and rodent studies, and when used orally or inject subcutaneously (under your skin) or intramuscularly (into your muscle).
Just take a look at the following, all of which was hunted down and identified by Suppversity in their article on BPC 157. BPC-157 has been shown to:
Promote tendon and ligament healing by tendon outgrowth, cell survival, and cell migration in a rodent model of Achilles tendon rupture, and also when administered in drinking water to rats with damaged medial collateral ligaments.
Counter the damaging effects of NSAIDs like ibuprofen or advil on the gut lining so effectively that scientists termed BPC 157 “a NSAIDs antidote” one of which they say that “no other single agent has portrayed a similar array of effects."
Repair the damage from inflammatory bowel disease (IBD) within just days of oral administration in a rodent model of IBD.
Help cure perdidontitis when administered in a rodent model of periodontitis, significantly enough to have scientists conclude that “BPC 157 may represent a new peptide candidate in the treatment of periodontal disease.“
Reverse systemic corticosteroid-impaired muscle healing, in a rodent models where BPC 157 was administered orally once daily for 14 days to rats with crushed gastrocnemius muscle. Similar benefits were demonstrated in a rodent study by Novinscak et al.
Accelerate bone healing in rabbits who suffered segmental bone defect before being treated with BPC 157.
BPC-157 is also known as a “stable gastric pentadecapeptide”, primarily because it is stable in human gastric juice, can cause an anabolic healing effect in both the upper and lower GI tract, has an antiulcer effect, and produces a therapeutic effect on inflammatory bowel disease (IBD) – all again surprisingly free of side effects.
As demonstrated in the research studies cited above, BPC 157 also accelerates wound healing, and, via interaction with the Nitric Oxide (NO) system, causes protection of endothelial tissue and an “angiogenic” (blood vessel building) wound healing effect. This occurs even in severely impaired conditions, such as in advanced and poorly controlled irritable bowel disease, in which it stimulates expression of genes responsible for cytokine and growth factor generation and also extracellular matrix (collagen) formation, along with intestinal anastomosis healing, reversal of short bowel syndrome and fistula healing – all of which can extremely frustrating issues in people who have gut pain, constipation, diarrhea and bowel inflammation.
BPC-157 protects the body from injuries, and also helps it heal previously acquired injuries, and is currently undergoing human trials . This is a list summing up most of the benefits this peptide is known to have (Source with citations) (4 of the references are not in the main source and were individually added):
Here's a list of additional observations noticed in BPC 157 trials:
- BPC-157 increases blood pressure in rats with low blood pressure.
- BPC-157 decreases blood pressure in rats with high blood pressure.
- BPC-157 protects from heart failure in a state of hyperkalemia (potassium overdose).
- BPC-157 protects from heart failure in a state of hypokalemia (potassium deficiency).
BPC-157 protects rats from damage (heart failure, pancreatitis, peptic ulcers) induced by hypercalcemia (calcium overdose).
BPC-157 protects rats from calcium channel blocker overdose.
- BPC-157 protects rats from hypermagnesemia (magnesium overdose).
BPC-157 significantly improves healing after the following injuries: skin incisions; deep skin burns; various anastomoses as intestinal wounds; diabetic wounds; various fistulas; various tissue transections, particularly ligament, tendon, muscle and nerve. Healing time of all these injuries is significantly decreased with BPC-157 administration.
BPC-157 prevents scar tissue buildup after injury, and reduces already existing scar tissue.
- BPC-157 modulates the immune system activates macrophages in the immune system, which leads to increased production of growth factors that fight infections, ultimately strengthening the immune system.
NSAID side effects and toxicity
- BPC-157 effectively reduces the side effects and toxicity of NSAIDs, particularly gastric, intestinal, liver and brain lesions, prolonged bleeding and various behavioural disturbances - all of these are significantly antagonized by BPC-157 administration.
- BPC-157 prevents and inhibits the effect of alcohol acute intoxication, withdrawal, and acute and chronic gastric and liver lesions.
- BPC-157 has antidepressant effects in rats; it reduces immobility time in a forced swimming test .
- BPC-157 reduces withdrawal symptoms in morphine-addicted mice.
BPC-157 reduces motor abnormalities and hyperactivity induced by the dopaminergic neurotoxin MPTP.
BPC-157 decreases chronic amphetamine-induced behavioral disturbances .
- BPC-157 is effective against serotonin syndrome in rats .
- BPC-157 significantly decreases diazepam tolerance, physical dependence and withdrawal symptoms in mice .
- BPC-157 significantly prolongs survival of rats with carcinoma and melanoma B-16 cancers, from 25 days to 45+ days.
BPC-157 prevents development of gastric ulcers.
BPC-157 heals existing gastric ulcers by reducing the ulcer area and accelerating the rebuilding of glandular epithelium and formation of granulation tissue.
Inflammation, pain and body temperature
BPC-157 successfully reduces several models of acute, non-specific inflammation.
BPC-157 acts against temperature decrease (i.e. water immersion test) and increase (yeast- induced).
BPC-157 increases pain threshold in carrageenan test in rats.
BPC-157 increases healing of skin wounds in diabetic animals.
BPC-157 prevents fructose-induced high blood pressure.
BPC-157 inhibits the development of insulin resistance.
BPC-157 improves healing of a transected sciatic nerve in rats, which is particularly shown as faster axonal regeneration.
BPC-157 strongly decreases the consequences of animal brain injuries induced by a falling weight.
BPC-157, given before infection of rats with hepatitis A virus, Lymphatic Choriomeningitis (LCM) virus and herpes virus types 1 and 2, completely prevented all signs of infection and disease.
BPC-157 given to rats after viral infection delays onset of disease symptoms and decreases death.
All citations to the papers demonstrating the benefits mentioned in the list can be found in the source linked at the top of the list (except for 4 which are stated in the list itself).
So if you have frustrating joint pain that won't go away, some kind of muscle tear, sprain or strain, or gut “issues”, you should potentially consider using BPC 157.
How Much BPC 157 To Take
There is an abundance of research on BPC-157 and it has been shown to be effective systematically when injected once daily at anywhere from 1-10mcg per kg of body weight. In most cases, this comes out to a dose of anywhere from 200mcg up to 800mcg. Some report the most success dosing twice per day with 250-350mcg for a total of 500-700mcg per day.
So as you can see, there's quite a bit of variability in dosage recommendations.
BPC 157 is both an Injection and Oral Treatment
BPC 157 acts systemically.
This means that whether you inject it subcutaneously – an easier and more-pain free under-the-skin method that you should do as close to the area of pain as possible…
….or you inject it intramuscularly – the more painful and teeth-gritting version of essentially “stabbing” the needle into the muscle as close to the injury as possible…
…or you simply spray it into your mouth orally…
…the BPC 157 going to render some amount of benefit in whichever part of your body needs healing. To what extent is still unknown.
Side Note: Datbtrue (Private Community of Athletes who self administered Peptides ) believed the best way of administration was to inject as close to the injury as possible.
Subcutaneous injections are also relatively simple. You can either pinch an area of skin near the injury site and thrust the needle into that pinched area of skin.
Intramuscular injections is the more painful option depending on the location of the injury as you're injection directly onto the damaged tissue and surrounding muscle tissue.
Oral administration of BPC 157 is quite straightforward where the user will spray onto the tongue (remember: very slowly to not damage the peptide), hold it in the mouth for 90-120 seconds, then swallow.
How Long To Take BPC 157
Based on the current human studies to date, BPC 157 can be safely administered for four weeks, followed by a two week rest. Again, this is just using the data we have, some have used longer and not reported any ill effects, but that doesn't mean there wasn't any.
Use In The Medical Field
Ok, so you may be now wondering why in the heck your physician, physical therapist, surgeon, gastroenterologist, etc. hasn't told you about this stuff.
Here's the deal: since BPC 157 is a completely natural gastric juice peptides, it's technically not patentable, period. That means big pharma can't make money off BPC 157, and that means it's not getting marketed to your local doctor or hospital or anywhere else in the health care system. It's also not available as an FDA regulated drug, or even considered to be “sellable” for human use.
Dr Rand Mcclain briefly speaks of BPC 157 in this short video.
https://youtu.be/ARA87WTIqcU?t=27s (Video starts at 27 seconds, but skip to 1:42 for the information below)
Who is Dr Rand Mcclain?
Dr Rand is a physician out in Santa Monica who consults World Strong Men, Elite Power-lifters, Top bodybuilders, movie stars and Olympic athletes. He is one of the few physicians who believe in Candida, Leaky gut, and the importance of the gut environment.
Video Summary: User asked a question on the formula for reconstituting BPC 157 which lead to Dr Rand explaining what World Strong Men patients (Who swear by BPC 157) have told him about their protocol
- Depending on the area, these patients injected 250 mcg in a triangular shape fashion.
- Next injection day you alternate, injecting on the areas you did not hit following the same triangular shape.
- These are strong men with powerful muscles / strong tendons, so maybe 250mcg x 3 is a lot, maybe 250mcg divided into 3 is all you need
- We don't have studies in this country in our medical system that uses BPC 157. He can not give a lot of information other than the anecdotal evidence of his patients.