One striking chart shows why pharma companies are fighting legal marijuana

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By [167]Christopher Ingraham July 13 [168]Follow @_cingraham
(Sarah L. Voisin/The Washington Post)

There's [169]a body of research showing that painkiller abuse and
overdose are lower in states with medical marijuana laws. These studies
have generally assumed that when medical marijuana is available, pain
patients are increasingly choosing pot over powerful and deadly
prescription narcotics. But that's always been just an assumption.

Now [170]a new study, released in the journal Health Affairs, validates
these findings by providing clear evidence of a missing link in the
causal chain running from medical marijuana to falling
overdoses. Ashley and W. David Bradford, a daughter-father pair of
researchers at the University of Georgia, scoured the database of all
prescription drugs paid for under Medicare Part D from 2010 to 2013.

They found that, in the 17 states with a medical-marijuana law in place
by 2013, prescriptions for painkillers and other classes of drugs fell
sharply compared with states that did not have a medical-marijuana law.
The drops were quite significant: In medical-marijuana states, the
average doctor prescribed 265 fewer doses of antidepressants each year,
486 fewer doses of seizure medication, 541 fewer anti-nausea doses and
562 fewer doses of anti-anxiety medication.

But most strikingly, the typical physician in a medical-marijuana state
prescribed 1,826 fewer doses of painkillers in a given year.


These conditions are among those for which medical marijuana is most
often approved under state laws. So as a sanity check, the Bradfords
ran a similar analysis on drug categories that pot typically is not
recommended for — blood thinners, anti-viral drugs and antibiotics. And
on those drugs, they found no changes in prescribing patterns after the
passage of marijuana laws.

"This provides strong evidence that the observed shifts in
prescribing patterns were in fact due to the passage of the medical
marijuana laws," they write.

[171]In a news release, lead author Ashley Bradford wrote, "The results
suggest people are really using marijuana as medicine and not just
using it for recreational purposes."

One interesting wrinkle in the data is glaucoma, for which there was a
small increase in demand for traditional drugs in medical-marijuana
states. It's routinely listed as an approved condition under
medical-marijuana laws, and [172]studies have shown that marijuana
provides some degree of temporary relief for its symptoms.

The Bradfords hypothesize that the short duration of the glaucoma
relief provided by marijuana — roughly an hour or so — may actually
stimulate more demand in traditional glaucoma medications. Glaucoma
patients may experience some short-term relief from marijuana, which
may prompt them to seek other, robust treatment options from their

The tanking numbers for painkiller prescriptions in medical marijuana
states are likely to cause some concern among pharmaceutical companies.
These companies have long been at the forefront of opposition to
marijuana reform, [173]funding research by anti-pot academics and
[174]funneling dollars to groups, such as the Community Anti-Drug
Coalitions of America, that oppose marijuana legalization.

Pharmaceutical companies have also lobbied federal agencies directly to
prevent the liberalization of marijuana laws. In one case,
[175]recently uncovered by the office of Sen. Kirsten
Gillibrand (D-N.Y.), the Department of Health and Human Services
[176]recommended that naturally derived THC, the main psychoactive
component of marijuana, be moved from Schedule 1 to Schedule 3 of the
Controlled Substances Act — a less restrictive category that would
acknowledge the drug's medical use and make it easier to research and
prescribe. Several months after HHS submitted its recommendation, at
least one drug company that manufactures a synthetic version of THC
— which would presumably have to compete with any natural derivatives
— [177]wrote to the Drug Enforcement
Administration to express opposition to rescheduling natural THC,
citing "the abuse potential in terms of the need to grow and cultivate
substantial crops of marijuana in the United States."

The DEA [178]ultimately rejected the HHS recommendation without

In what may be the most concerning finding for the pharmaceutical
industry, the Bradfords took their analysis a step further by
estimating the cost savings to Medicare from the decreased prescribing.
They found that about $165 million was saved in the 17 medical
marijuana states in 2013. In a back-of-the-envelope calculation, the
estimated annual Medicare prescription savings would be nearly half a
billion dollars if all 50 states were to implement similar programs.

"That amount would have represented just under 0.5 percent of
all Medicare Part D spending in 2013," they calculate.

Cost-savings alone are not a sufficient justification for implementing
a medical-marijuana program. The bottom line is better health, and the
Bradfords' research shows promising evidence that medical-marijuana
users are finding plant-based relief for conditions that otherwise
would have required a pill to treat.

"Our findings and existing clinical literature imply that patients
respond to medical marijuana legislation as if there are clinical
benefits to the drug, which adds to the growing body of evidence
suggesting that the Schedule 1 status of marijuana is outdated," the
study concludes.

One limitation of the study is that it only looks at Medicare Part D
spending, which applies only to seniors. Previous studies have shown
that seniors are among the most reluctant medical-marijuana users, so
the net effect of medical marijuana for all prescription patients may
be even greater.

The Bradfords will next look at whether similar patterns hold for
Anne McDonald Pritchett, Vice president of policy and research for
PhRMA, discusses prescription drug abuse. The discussion took place
during Coffee@WaPo: A policy conversation about addiction in America.
(Washington Post Live)