2018
"A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Assessing Safety, Tolerability, and Efficacy of Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer’s Disease"
https://www.scribd.com/document/394908904/10-3233-JAD-180759
"Loss in PKC Epsilon Causes Downregulation of MnSOD and BDNF Expression in Neurons of Alzheimer’s Disease Hippocampus"
“Bryostatin-1 alleviates experimental multiple sclerosis”
https://www.scribd.com/document/386853846/Bryostatin-1-alleviates-experimental-multiple-sclerosis
2017
“ApoE isoforms differentially regulates cleavage and secretion of BDNF”
"Bryostatin Effects on Cognitive Function and PKC epsilon in Alzheimer’s Disease Phase IIa and Expanded Access Trials"
“Effects of chronic bryostatin-1 on treatment-resistant depression in rats”
2016
"PKC epsilon Promotes Synaptogenesis through Membrane Accumulation of the Postsynaptic Density Protein PSD-95"
http://www.jbc.org/content/291/32/16462.full.pdf?with-ds=yes
“Rescue of Synaptic Phenotypes and Spatial Memory in Young Fragile X Mice”
2015
“ApoE4 and Ab Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation”
“Towards universal therapeutics for memory disorders”
https://www.scribd.com/document/386855087/Towards-universal-therapeutics-for-memory-disorders
“Identification of the PS1 Thr147Ile Variant in a Family with Very Early Onset Dementia and Expressive Aphasia”
2014
“The “Memory Kinases””
https://www.scribd.com/document/386855405/The-Memory-Kinases
“Molecular Regulation of Synaptogenesis during Associative Learning and Memory”
"Bryostatin-1 Restores Blood Brain Barrier Integrity following Blast-Induced Traumatic Brain Injury"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000781/pdf/nihms810689.pdf
"PKC epsilon Deficits in Alzheimer’s Disease Brains and Skin Fibroblasts"
"Common Mechanisms of Alzheimer’s Disease and Ischemic Stroke: The Role of Protein Kinase C in the Progression of Age-Related Neurodegeneration"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446718/pdf/nihms659711.pdf
"Fibroblast Aggregation Rate Converges with Validated Peripheral Biomarkers for Alzheimer’s Disease"
"PKC epsilon Promotes HuD-Mediated Neprilysin mRNA Stability and Enhances Neprilysin-Induced Ab Degradation in Brain Neurons"
http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0097756&type=printable
"Bryostatin-1 Restores Hippocampal Synapses and Spatial Learning and Memory in Adult Fragile X Mice"
http://jpet.aspetjournals.org/content/jpet/349/3/393.full.pdf
“PKC activators enhance GABAergic neurotransmission and paired-pulse facilitation in hippocampal CA1 pyramidal neurons”
2013
“Bryostatin Improves Survival and Reduces Ischemic Brain Injury in Aged Rats After Acute Ischemic Stroke”
“Cerebral ischemia-induced difference in sensitivity to depression and potential therapeutics in rats”
“PKC activation during training restores mushroom spine synapses and memory in the aged rat”
2012
"Spatiotemporal Complexity of Fibroblast Networks Screens for Alzheimer’s Disease"
“Activation of Protein Kinase C Isozymes for the Treatment of Dementias”
"Apolipoprotein E3 (ApoE3) but Not ApoE4 Protects against Synaptic Loss through Increased Expression of Protein Kinase C epsilon"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346146/pdf/zbc15947.pdf
2011
"PKC epsilon Activation Prevents Synaptic Loss, Ab Elevation, and Cognitive Deficits in Alzheimer’s Disease Transgenic Mice"
http://www.jneurosci.org/content/jneuro/31/2/630.full.pdf
2010
“PKC activator therapeutic for mild traumatic brain injury in mice”
“Pharmacology of protein kinase C activators: Cognition-enhancing and antidementic therapeutics”
“PKC and Insulin Pathways in Memory Storage: Targets for Synaptogenesis, Anti-apoptosis, and the Treatment of AD”
2009
“Protein Kinase C Activators as Synaptogenic and Memory Therapeutics”
"Postischemic PKC activation rescues retrograde and anterograde long-term memory"
http://www.pnas.org/content/pnas/106/34/14676.full.pdf
“A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Aβ-induced biomarker abnormality on cultured fibroblasts”
“Neuroprotective versus tumorigenic protein kinase C activators”
2008
"Poststroke neuronal rescue and synaptogenesis mediated in vivo by protein kinase C in adult brains"
http://www.pnas.org/content/pnas/105/36/13620.full.pdf
“Analysis of long-term cognitive-enhancing effects of bryostatin-1 on the rabbit (Oryctolagus cuniculus) nictitating membrane response”
“Synergistic effects of chronic bryostatin-1 and α-tocopherol on spatial learning and memory in rats”
2007
"A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC"
http://www.pnas.org/content/pnas/104/49/19571.full.pdf
"PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer’s disease"
2006
“Protein Kinase C Pharmacology: Perspectives on Therapeutic Potentials as Antidementic and Cognitive Agents”
"Bryostatin Enhancement of Memory in Hermissenda"
http://www.journals.uchicago.edu/doi/pdfplus/10.2307/4134558
“Bryostatin-1: Pharmacology and Therapeutic Potential as a CNS Drug”
2005
"Protein synthesis required for long-term memory is induced by PKC activation on days before associative learning"
http://www.pnas.org/content/pnas/102/45/16432.full.pdf
“Protein Kinase C Isozymes: Memory Therapeutic Potential”
https://www.scribd.com/document/386868151/Protein-Kinase-C-Isozymes-Memory-Therapeutic-Potential
“Protein kinase C substrate activators: Potential as novel antidepressants”
“Dual effects of bryostatin-1 on spatial memory and depression”
2004
"Therapeutic effects of PKC activators in Alzheimer’s disease transgenic mice"