Adverse Events
In most cases, both drugs are well tolerated, but occasionally side effects slip through. So, the reception of “Lorista” can lead to such negative phenomena as:
When taking Lorista, nasal congestion may be observed in patients.
- headache of varying severity;
- sleep disturbances;
- low blood pressure, dizziness;
- fatigue, general weakness;
- painful abdominal discomfort, vomiting;
- heart palpitations;
- "Angina pectoris", shortness of breath;
- frequent loose stools;
- dry oral mucosa;
- swelling or nasal congestion;
- impaired renal function;
- inflammation of the gastric mucosa;
- cough, bronchitis;
- cramps, muscle, joint pain;
- taste change, visual impairment;
- dry skin, itching, rash.
Taking lisinopril, there is a chance to encounter side symptoms, including:
While taking such a medicine, a person can suffer a cough.
- low blood pressure;
- allergic rashes on the skin;
- excruciating cough;
- gastrointestinal upset;
- pain in the temples and neck;
- hallucinations;
- impotence;
- nasal congestion;
- a drop in plasma sugar;
- shortness of breath.
History
Captopril, the first ACE inhibitor, is a functional and structural analogue of a peptide derived from the haracasa venom, the Brazilian viper (Bothrops jararaca). Enalapril is a derivative developed by scientists from Merck to overcome the bad taste of captopril. Enalapril is actually a prodrug; the active metabolite is enalaprilat. Lisinopril is a synthetic peptidic derivative of captopril. Scientists from Merck created lisinopril, systematically changing each structural unit of enalaprilat, replacing various amino acids. It turned out that the addition of lysine at one end of the drug added activity and the substance became available orally. An analogue of this compound is lisinopril, which got its name from the discovery with lysine. Merck conducted clinical trials, and the drug was approved for the treatment of hypertension in 1987 and heart failure in 1993. The discovery created a problem because Merck's enalapril sales were high and the company did not want to reduce these sales. As a result, Merck entered into an agreement with Zeneca, according to which Zeneca received the right to joint marketing of lisinopril, and Merck received exclusive rights to an earlier stage of the use of an aldose reductase inhibitor drug, a potential treatment for diabetes. Zeneca's marketing and brand name, Zestril, proved stronger than Merck's efforts. The drug became a blockbuster for Astrazeneca (created in 1998), annual sales in 1999 amounted to 1.2 billion US dollars. The US patent expired in 2002. Since then, Lisinopril (https://perfecthealthus.com/buy-zestril-10mg-5mg-2-5mg-lisinopril-online/) has been available under many trademarks around the world; some formulations include hydrochlorothiazide diuretic.
Contraindications
The drug should not be taken with hypersensitivity to its components, lactation and pregnancy.
It is undesirable to prescribe this remedy for:
- hyperkalemia
- anaphylactoid reactions;
- collagenoses;
- cerebrovascular insufficiency;
- impaired kidney and liver function;
- bilateral renal artery stenosis;
- transplanted kidney;
- gout
- advanced age;
- a history of Quincke's edema;
- bone marrow depression;
- hypotension;
- obstructive changes that prevent the outflow of blood from the heart;
- hyponatremia, as well as when eating with a limited intake of sodium;
- stenosis of a single kidney artery;
- hyperuricemia;
- childhood.
Heart failure
Lisinopril-Teva is prescribed in addition to the existing therapy with diuretics and digitalis.
The initial dose is 2.5 mg in the morning.
The maintenance dose should be established in stages with increases of 2.5 mg with an interval of 2 to 4 weeks.
The usual maintenance dose is 5 to 20 mg once daily.
Do not exceed the maximum dose of 35 mg of lisinopril / day.
Side effects
Side effects can be different, they arise from different systems and organs:
- nervous system - irritability, headache, ataxia, increased fatigue, transient cerebrovascular accident, tremor, drowsiness, blurred vision, confusion, nervousness, fainting, peripheral neuropathy, memory loss, dizziness, insomnia, paresthesia, cramps, tinnitus;
- gastrointestinal tract - dry mouth, heartburn, vomiting, flatulence, abdominal pain, gastritis, indigestion, nausea, diarrhea, constipation, cramping, hepatotoxicity, pancreatitis;
- musculoskeletal system - arthralgia, myalgia, arthritis, neck and back pain;
- respiratory system - malignant tumors of the lungs, embolism and pulmonary infarction, dry cough, asthma, respiratory pain, hemoptysis, laryngitis, pharyngitis, nosebleeds, paroxysmal postural dyspnea, infiltration, pleural effusion, rhinitis, bronchitis, bronchospasm, sinus;
- genitourinary system - acute renal failure, problems with kidney function, pyelonephritis, oliguria, uremia, impotence, dysuria, anuria, edema, decreased libido;
- skin - urticaria, alopecia, pemphigus, Lyell syndrome, photosensitivity, rash, damage and infection of the skin, Stevens-Johnson syndrome.
In addition, the following manifestations are possible: the development of infections, weight loss, sweating, diabetes mellitus, an increase in the titer of antinuclear antibodies and urea, gout, an increase in creatinine, hyperkalemia, hyperuricemia, fever, allergy, dehydration, hyponatremia.
If any side effects are detected, you should immediately consult a specialist.